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Brown atrophy of the liver is observed in the course of diseases associated with failure and inferiority of nutrition: idiopathic pyloric stenosis or gastric / doudenalna ulcer, cancer of the stomach and esophagus, cachexia, incl. and senile, diseases of the endocrine glands etc.. Macroscopically, the liver is reduced in size to brownish, thickened and sharp edge. Histological picture is represented by thin gredichki liver, mainly in centrilobular areas. Delchetata are reduced in size and portal spaces appear dilated. Hepatocytes around v. centralis are reduced in size (atrophic) in the cytoplasm, perinuklearno, there is accumulation of yellow-brown pigment - lipofuscin.
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