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A. cellular composition - mainly smooth muscle, macrophages and T - lymphocytes
2. extracellular matrix including collagen, elastic fibers, proteoglycans and
3. intra-and extracellularly deposited lipids, cholesterol crystals
These components are found in different proportions and configurations for different lesions. Most often the surface of plaques in the aorta ateromatoznite visible fibrous layer ("top") composed of smooth muscle cells and relatively dense collagen. Below it is the necrotic core of plaque, etc.. etc. athera, containing lipids, cholesterol and cholesterol esters, detritus from dead cells and foam cells. In the periphery of the lesion is an area of neovascularisation, proliferation of small blood vessels. In advanced atherosclerotic plaques are found in calcifications. On histological preparation of the aorta is seen splitting cadovata wall between intimate and media blanks and optical processing of soluble holesterinovite crystals and lipids
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